Single molecule fluorescence detection Microscopy
Single molecule fluorescence detection Microscopy
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AttoBright is a compact, plug-and-play single-molecule fluorescence detection microscope developed by AttoQuest. It enables researchers to detect, count, and characterize individual fluorescent molecules and nanoparticles with single-molecule sensitivity. |
Summarize:
AttoBright is a compact, plug-and-play single-molecule fluorescence detection microscope developed by AttoQuest. It enables researchers to detect, count, and characterize individual fluorescent molecules and nanoparticles with single-molecule sensitivity.
Unlike conventional bulk fluorescence measurements, AttoBright analyzes individual particles one by one, allowing researchers to study molecular heterogeneity, rare events, and nanoscale biological interactions with unprecedented sensitivity.
The system combines advanced optics, automated data acquisition, and intelligent analysis software into a compact instrument suitable for both research laboratories and future clinical translation.
Advantage：
True single-molecule sensitivity
Detects individual particles instead of averaged signals
Approximately one million times higher sensitivity than conventional bulk assays
Measures sample heterogeneity
Quantitative particle counting
Compact desktop instrument
Plug-and-play operation
Minimal sample volume
Automated analysis software
Fast measurement
Expandable optical configuration
Features：
True single-fluorophore resolution enables detection of monomers, dimers, trimers, and higher-order molecular assemblies
Nano-positioning optics
Avalanche photodiode detector
Extremely low background noise
True Quantification: Count Every Particle
Minimal Sample Volume: 10 μL Sample
Rapid Analysis: 60 seconds
Automated Analysis
Flexible Fluorescence Configuration
Application：
Protein Aggregate Detection
Protein-Protein Interaction
Liposome Analysis
Micelle Characterization
Nanoparticle Detection
Extracellular Vesicles (Potential Application)
Bacterial Detection
Clinical Biomarker Research
Detailed Specifications
Technical paramter：
Detection Principle： Single Molecule Fluorescence Detection
Detector ：Avalanche Photodiode (APD)
Resolution： Single Fluorophore
Detection Size： 5 nm – 5 μm
Sample Volume： As low as 10 μL
Acquisition Time： Typically 60 seconds
Dynamic Range： Over 4 orders of magnitude
Weight： 1.2 kg
Dimensions： 15 × 21 × 18 cm
Software： Fully automated
Expansion： Additional lasers & detectors available
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