Nano-scale Temperature Controller for Single Cells and Organoids

You Are Here ：HOME > PRODUCTS > Nano-scale Temperature Controller for Single Cells and Organoids >

Nano-scale Temperature Controller for Single Cells and Organoids
description：	DHTIS THE ONLY TOOL WHICH COMBINES TEMPERATURE MEASUREMENT AND THERMAL STIMULATIONIN A SINGLE PARTICLE

Diamond HeaterThermometer （DHT)
DHTIS THE ONLY TOOL WHICH COMBINESTEMPERATURE MEASUREMENT AND THERMAL STIMULATIONIN A SINGLE PARTICLE
An elegant solution consisting of a glass capillary and a single diamondcrystal, DHT allows one to reliably induce desired level of ultra-local heating andprecisely measure temperature changes at the nanoscale.
Thermosensitive silicon-vacancy (SiV) color centers in diamond enable purelyoptical temperature readout in the near-infrared range. No bulky electric circuitsneeded.
Unprecedented temporal and spatial resolution allows you to implementsarbitrary thermal protocols and apply them to a variety of solid-state and biologicalsystems, from ion channels to multicellular organoids.
Main features
PERFORM STABLE AND RELIABLE MEASUREMENTS
Thanks to the properties of diamond, the DHThas infinite photo stability and is insensitive to the effects of the environment (PH, magnetic orelectricfield), makingyour temperature measurements fully reliable.
WORK IN THE BIOLOGICAL TRANSPARENT WINDOW
The fluorescenceof the siv-centers lies in thenear-infrared,soyoucan use the DHT with any sensitive biological samples.
CONTROL THE FASTEST PROCESSES
DHT allows you to define custom ultra fast temperature protocols, with millisecond steps in the detection mode and microsecond for the heating.
CHOOSE OPTIMAL DIAMONDS
wide range of diamond particle sizes available, from 50nm upto hundreds of microns.

core technology
TheDHT technology is base dona single engineered diamond micro or nano particle place don the tipo fa pulled glass pipette. This diamond particle has two main features:
1. It contains atomic defects in its crystalline lattice called silicon vacancy(siv)color centers, which act as quantum sensors and enable all optical fluorescencebased thermometry.
2. It possesses amorphous carbon at its intercrystalline boundaries,making it an efficient light absorber and effectively turning it into an ultra-local nanoscale heat source.

Example applications
spatially-selectivethermalstimulation of single ion channel sand their clusters on living cells'membranes
ultra-local thermal stimulation of living cells' division
Thermal stimulation of inter-neuron al synaptic contacts formation
Research on disease biology(e.g.Alzheimer's, parkinson's, epilepsy) through ion channel sand nano scale thermodynamics
Thermal nano scale manipulation of calcium concentration gradients inside a living cell
Thermal control of cytoskeletal intracellular structures'growth, directed by microscopic thermal gradient
ultra-local method ofthermal lethal action on individual(cancerous) cells inside living tissue
spatially-resolved thermalaction to terminate pathological epileptic processes inside brain structures

PRODUCTS

Nano-scale Temperature Controller for Single Cells and Organoids

Detailed Specifications

CONTACT US

PRODUCTS

APPLICATION

Follow us