Basic Introduction:

Scissor N3 is an in vitro model simulating subcutaneous injection of biopharmaceuticals for rank ordering formulations and excipient screening during formulation development.

Understand in vitro how a drug behaves after subcutaneous injection and the impact this has on drug release with our Scissor N3.

Reduce the reliance on inaccurate animal models and select formulation candidates with confidence based on bio-relevant information gained earlier in the development process, saving in both cost and time.

The Scissor N3 mimics the stresses a biopharmaceutical experiences when transitioning from formulation conditions to a subcutaneous environment.

Possible precipitation events can be monitored and correlated to lymphatic and systemic release dynamics quantified in the system.

Scissor allows users to screen excipients and compare different formulations to identify the best candidates for further development.

Compatible with an optional fraction collector.

Product Advantages:

SCISSOR N3 is the only commercially available scientific instrument designed as a bridge for in vivo pharmacokinetic (PK) studies and in vitro drug release and dissolution performance assessment.

SCISSOR N3 can conduct 3 independent experiments simultaneously, while SCISSOR N6 allows for up to 6 experiments.

Optional automatic sample collector with programmable sampling volume and frequency, featuring 240 collection positions and automatic replenishment.

Integrated camera and turbidity sensor enable efficient turbidity detection, assessing drug precipitation or particle dissolution behavior.

Compatible with Rainbow R6 fiber optic probes for online drug concentration monitoring, providing concentration vs. time profiles.

Maintains physiological relevant temperature and buffered environment throughout experiments.

Capable of monitoring pH changes at injection sites within the extracellular matrix (ECM).

Optimal selection of ECM simulates realistic subcutaneous environments.

Product Key Features:

Gain biorelevant data about your subcutaneous sample in vitro

Coupled with the Rainbow R6 in-situ fiber optic UV-vis spectrometer, lymphatic and systemic release data can be measured in-situ giving real-time results and enriching the data collection process.

Sample aliquots can also be collected with an additional external fraction collector to allow for offline analysis with any preferred analytical method facilitating more in-depth research.

Application：

The Scissor N3 is an exciting branch of the Pion technology helping users understand formulations

Excipient screening during formulation development

Formulation comparison

Rank ordering formulations for candidate selection

Investigation of drug stability upon and after injection

Detailed Specifications

Specification

PH Range: 4-10, fluctuation range of +1/-0.05 pH
Outer chamber temperature: 34°C; adjustable from 30-40°C
Stability: +1/-1.0°C (24 hours), temperature equilibrium time <1 hour
Camera capture speed: 2 images/minute
Pump flow rate: >25 mL/minute
Liquid transfer time (outer chamber to sampling point): <30 seconds
Stirring speed: Optional
LED wavelength: 504 nm