Basic Introduction:
The Dynamic42 biochip is a microfluidic platform that facilitates physiologic cell and tissue culture. Its microscopic slide-like design fits in every lab environment and helps you to scale up your cell co-culture. Different channel dimensions offer tremendous options to maximize your readouts, to enrich secreted molecules or to safe precious cell material. Its superior material efficiently limits adsorption of small hydrophobic molecules to the surface. The easy handling of our lab-on-a-chip technology ensures workflows for you. Leverage your cell culture dynamically onto the next level.


Product Advantages:
Increasing Biological Relevance. 3dimensional settings, multicellular models that include all relevant cell types including the human immune system and the application of biomechanical cues such as perfusion improve the cell’s responsiveness and scientific data quality.
Improved prediction and risk assessment. Working in fully human settings with increased biological relevance and data quality and less animal-derived data will improve prediction and risk assessment of new drugs before entering human clinical trials.
Reduction in animal testing. The Organ-on-Chip technology bears the power to reduce animal testing significantly and sustainably in the future.
High Flexibility. Organ-on-Chip is a highly flexible technology in many ways. Applications profit from a variety of materials, technical biology-driven design possibilities and the combinations with other cutting-edge technologies such as sensors and microscopy. On a biological level, scaling of cells and cell types renders Organ-on-Chip a highly valuable tool for mechanistical studies.
Product Key Features:
The Dynamic42 biochip is provided in a microscopic slide format well adapted to the standard cell culture lab environment. It is made from biocompatible thermoplastics with low adsorption characteristics for small hydrophobic molecules. The microfluidic chip is tightly bonded with biocompatible plastic foils on the top and bottom. It comprises two individually operatable cavities for cell culture applications. The cavities are subdivided by a porous polymer membrane into a top and into a bottom channel. The membrane is tightly sealed into the cavities and customizable in terms of polymer material, pore size and pore density. The Dynamic42 biochip connects via standard luer ports to perfusion tubing and pump equipment. The luer format is widely established in lab and medical devices. There are different channel and cavity dimensions available supporting volumes from 55 µl to 140 µl.
The Dynamic42 Biochip is an easy-to-handle lab-on-chip device built for reliable cell culture research and emulating organs on chips. Its channel design supports air bubble-free microfluidic applications.

Detailed Specifications

Specification

Dimensions：

microscopic slide format

75 mm x 25 mm

Material specifications：

medical grade plastics

biocompatible

low drug adsorption

Membrane：

various polymers (PET ect.)

various pore sizes

tightly sealed

standard configuration

Connection and compatibility：

via standard luer ports, operatable with any tubing-based perfusion system (peristaltic and syringe)

ports and cavities arranged in microtiter plate positions, with plate readers and pipetting robots (SBS standard)

Cell culture：

static or perfused

scalable from single cell type up to complex co-culture arrangements

perfusion of PBMCs or immune cell subpopulations

Optics：

clear top and bottom bonding foils enable brightfield and fluorescence microscopy

live cell imaging possible, no extra adapter needed for microscopic slide format

optional: bottom bonding with glass slide for superior imaging