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CellWave Sorter

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CellWave Sorter
description：	CellWave Acoustic Microfluidics non-destructive cell sorting system -- a next-generation cell sorting platform based on acoustic microfluidics technology. Whether you are engaged in cell therapy, immunology research, oncology analysis, or rare cell captur

CellWave Acoustic Microfluidic Label-Free Cell Sorting System
CellWave is a next-generation cell sorting platform based on Acoustic Microfluidics technology. Whether you're working in cell therapy, immunology, oncology, or rare cell isolation, CellWave offers a label-free, non-invasive, high-purity cell sorting solution. It is a truly damage-free platform for cell sorting!
Technical Advantages
1.Non-invasive Sorting
Cell sorting is achieved using acoustic waves, maintaining low shear force throughout the process and preserving the natural state of cells. It is particularly suitable for sensitive samples such as stem cells, extracellular vesicles (EVs), and primary cells.
2.Ultra-high Purity and Recovery
By precisely manipulating cells with acoustic standing wave fields, sorting purity exceeds 95%, and recovery rates exceed 80%—greatly surpassing traditional methods like FACS (Fluorescence-Activated Cell Sorting) or MACS (Magnetic-Activated Cell Sorting) in gentleness.
3.High Throughput and Automation
With a processing speed of up to 10⁶ cells/min, CellWave supports continuous sorting, minimizing manual errors. Integrated smart software allows one-click parameter setup, enabling easy and reproducible experiments.
4.Versatile Compatibility
Compatible with a variety of sample types, including blood, tissue dissociates, and cultured cells. Its modular design supports custom sorting strategies, such as sorting based on cell size, density, or mechanical properties.
Technology Principle
CellWave uses high-frequency ultrasound (MHz range) to generate a stable standing acoustic wave field inside a microfluidic chip. This allows non-contact manipulation of cells or particles through Acoustic Radiation Force:

Standing Acoustic Wave Field
Generated by a piezoelectric transducer, creating periodic high/low-pressure nodes inside the microchannel.
Acoustic Radiation Force
Cells are driven by pressure differentials in the acoustic field, migrating toward pressure nodes or antinodes, depending on their physical characteristics.
Sorting Mechanism
Cells of different sizes, densities, or mechanical properties respond differently to acoustic forces, enabling precise separation.
Operation Workflow
Sample Injection
Cell suspensions flow through the microfluidic channel under laminar flow conditions.
Acoustic Field Activation
High-frequency ultrasound is activated, forming a standing wave field. Cells concentrate at pressure nodes.
Sorting and Output
Target cells: Deflected by acoustic forces and collected at the designated outlet.
Non-target cells: Flow along the waste channel for removal.
Gentle Recovery
Sorted cells maintain high viability and are ready for direct downstream culture or analysis.
Core Application Areas
Cell Therapy and Regenerative Medicine
Sorting of stem cells (e.g., CAR-T, iPSC preparation) to ensure the safety and consistency of clinical-grade cell products.
Cancer Research and Liquid Biopsy
Efficient enrichment of circulating tumor cells (CTCs) and extracellular vesicles, supporting early cancer screening and treatment monitoring.
Immunology and Infectious Diseases
Sorting of rare immune cells (e.g., antigen-specific T cells), accelerating vaccine development and immune response studies.
Microbiology and Synthetic Biology
High-throughput sorting of bacteria and yeast, optimizing strain selection and biomanufacturing processes.

Advantages Compared to Other Sorting Technologies

Parameters	CellWave sound wave sorting	Conventional Flow Sorting (FACS)	Magnetic bead sorting (MACS)
Cell damage	no	Laser/voltage damage cells	Antibody labeling may activate the cells
Labeling requirements	Not required (can be marked if the sample has special requirements)	Fluorescently labeled	Magnetic bead labeling is required
Flux	High (continuous flow)	High (Single cell detection)	Low (Batch processing)
Cost-effectiveness	Low initial purchase cost and simple later maintenance	The initial purchase cost is high, and the later maintenance cost of the laser is high	The initial purchase cost is high, and the later use cost of the magnetic beads is high

Detailed Specifications

Classification	Parameters (English)	Parameters (Chinese)	Specifications
Optical system	Laser	Laser wavelength	488 nm
	Fluorescence Filter	Fluorescence filter	530/43 nm
	Detectors	Detector	FITC (Fluorescence), FSC (forward scattering)
Fluid systems	Sample input
	Maximum Input Sample Volume	Maximum sample volume	600 µL
	Minimum Input Sample Volume	Minimum sample volume	150 µL
	Recommended Input Volume	Recommended sample volume	150-300 µL
	Recommended Concentration	Recommended sample concentration	0.5-1.5×10⁶ cells/mL
	Maximum Sheath Volume	Maximum sheath volume	1.2 mL
	Max Sheath Pressure	Maximum sheath fluid pressure	5 PSI
	Recommended Sheath Pressure	Recommend sheath pressure	2.25 PSI
Output and Performance	Output Containers	Output containers	2×1.5 mL EP tubes
	Throughput	Flux	10,000 cells/sec
	Max Sample Pressure	Maximum sample pressure	2 PSI
	Recommended Sample Pressure	Recommended sample pressure	1 PSI

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