Basic Introduction:

The AccuLift™ Spatial Profiler system is an unparalleled Spatial Biology profiling system that harnesses the power of a cloud-based platform into one unique digital pathology ecosystem to study the complex tissue microenvironment. As part of a complete spatial biology workflow that includes a novel suite of reagents and software, the AccuLift™ Spatial Profiler system is designed to meet the needs of researchers and pathologists to transform spatial molecular profiling and accelerate precision medicine.

Product Advantages:

Precise，Exact spatial molecular profiling down to single cell levels.

Flexible，Profile targeted regions of interest (ROIs) within the tissue microenvironment or the whole section.

Seamless Integration，Used with standard histology protocols for a minimal set-up period.

Comprehensive，Multiomic profiling (WGS, RNA-seq, LC-MS,

RPPA) with spatial contexts.

Application：

Oncology，Study specific tumor and nontumor cells within heterogeneous tumor microenvironment.

Neuroscience，Analyze the thousands of cell types within heterogeneous central nervous system.

Single Cells，Profile single cells based on morphology, spatial biology or in situ biomarkers.

Proteomics，Spatially resolved and cell-specific proteomic analysis by mass spectrometry.

Genomics，Profile the genome and transcriptome by next-generation sequencing or qPCR.

Specification

Microscope：Olympus ix73 microscope base. Standard microscope operation outside of LCM operating software. Nikon Ti2 Microscope Base.

Laser: Infrared (IR) Capture Laser: Solid-state, near-IR (808 nm) with adjustable power output. Infrared (IR) Capture Laser: Solid-state, blue (450 nm) with adjustable power output UV Laser: Solid-state, passive Q-switched, diode-pumped (355 nm), UV Laser: Solid-state, diode-pumped Q-switched (349 nm) with adjustable laser current and pulse frequency.

Illumination: 5W 24-LED illumination ring.

Objectives: 2x, 10x, and 40x Olympus PLAPON; PLAN APO objectives 4x, 20x, 60x, and 100x dry.

Stage: Motorized, joystick- or software-actuated in X and Y axes with 0.25 µm homing accuracy and 0.25 µm bidirectional reproducibility for autonomous microdissection. Click-and-walk technology.

Contrast methods: Bright field.

Microdissection camera: Color CMOS camera with large field of view andhigh resolution (5MP), low noise, frame rate of 75fps at the full 5MP resolution.

Black and white CMOS camera with large field of view and high resolution (5MP), low noise, frame rate of 75fps at the full 5MP resolution.

Detailed Specifications